Wissentschaftlich fundiert: Publikationen und Studien


LiV signals can prevent postmenopausal bone loss
Rubin C, Recker R, Cullen D, Ryaby J, McCabe J, McLeod K; Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety. Journal of Bone and Mineral Research 19, 343-351 (2004)

LiV signals to improve bone density
Kiel D, Hannan MT, Barton BA, Bouxsein ML, Sisson E, Lang T, Allaire B, Dewkett D, Carroll D, Magaziner J, Shane E, Leary ET, Zimmerman S; Low-Magnitude Mechanical Stimulation to Improve Bone Density in Persons of Advanced Age: A Randomized, Placebo-Controlled Trial. Journal of Bone and Mineral Research: the official journal of the American Society for Bone and Mineral Research 30, 1319-1328, doi:10.1002/jbmr.2448 (2015)

LiV signals enhance musculoskeletal health of young women
Gilsanz V, Wren TA, Sanchez M, Dorey F, Judex S, Rubin C; High-frequency mechanical signals enhance musculoskeletal development of young women with low BMD. Journal of Bone and Mineral Research 21, 1464-1474 (2006)

LiV signals to inhibit bone loss in elderly women
Hannan M, Marian T, Cheng DM, Green E, Swift C, Rubin C, Kiel D; Establishing the compliance in elderly women for use of a low-level mechanical stress device in a clinical osteoporosis study. Osteoporosis International 15, 918-926, doi:10.1007/s00198-004-1637-y (2004).

WBV – Safety of accelerations
Muir J, Kiel, Rubin C; Safety and severity of accelerations delivered from whole body vibration exercise devices to standing adults. Journal of science and medicine in sport / Sports Medicine Australia, doi: 10.1016 / j.jsams.2013.01.004 (2013)

LiV signals to improve muscle strength and balancing ability for effective fall prevention
Leung KS, Li CY, Tse YK, Choy TK, Leung PC, Hung VW, Chan SY, Leung AH, Cheung WH; Effects of 18-month low-magnitude high-frequency vibration on fall rate and fracture risks in 710 community elderly – a cluster-randomized controlled trial. Osteoporosis International (2014)

LiV signals may provide a non-pharmacological treatment for bone fragility in children
K, Alsop C, Caulton J, Rubin C, Adams J, Mughal Z; Low-magnitude mechanical loading Is osteogenic in children with disabling conditions. Journal of Bone and Mineral Research (2004)

LiV signals could translate into a decreased risk of long bone fractures
Wren TLA, Lee DC, Hara R, Rethlefsen SA, Kay RM, Dorey FJ, Gilsanz V; Effect of high-frequency, low-magnitude vibration on bone and muscle in children with cerebral palsy. Journal of pediatric orthopedics (2010)

LiV signals to examine the effects on bone and muscle strength in children
Bianchi ML, Vai S, Morandi S, Baranello G, Pasanisi B, Rubin C; Effects of low-magnitude high-frequency vibration on bone density, bone resorption and muscular strength in ambulant children affected by Duchenne muscular dystrophy. ASMBR Oral Paper (2013)

LiV signals to improve physical fitness in children and adolescents
Matute-Llorente A, González- Aguero A, Gómez-Cabello A, Vicente-Rodríguez G, Casajús Mallén JA; Effect of whole-body vibration therapy on health-related physical fitness in children and adolescents with disabilities: A Systematic Review. Journal of Adolescent Health (2014)

LiV signals to enhance bone density in girls with idiopathic scoliosis
Lam TP, Ng BKW, Cheung LWH, Lee KM, Qin L, Cheng JCY; Effect of whole-body vibration (WBV) therapy on bone density and bone quality in osteogenic girls with adolescent idiopathic scoliosis: a randomized, controlled trial. Osteoporosis International (2013)

Mechanical signals promote bone and muscle anabolism while limiting formation and expansion of fat mass. Mechanical signals, such as those induced through low-intensity vibration, need not be large in magnitude, or long in duration, to influence bone or fat phenotypes Gabriel M. Pagnotti, Maya Styner, Gunes Uzer, Vihitaben S. Patel, Laura E. Wright, Kirsten K. Ness, Theresa A. Guise, Janet Rubin & Clinton T. Rubin. Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity. Nature Reviews Endocrinology (2019)

LiV signals help childhood cancer survivors with bone density
Kirsten K. Ness, The effects of low magnitude high frequency mechanical stimulation (LMS) on bone density in childhood cancer survivors (CCS), Podium Presentation, APTA CSM Indianapolis Feb 2015

LiV signals may prevent osteoporosis
Ward, K. et al. Low magnitude mechanical loading is osteogenic in children with disabling conditions. J. Bone Miner. Res. 19, 360-369 (2004). DOI: 10.1359/JBMR.040129

LiV signals strengthen long bone
Rubin, C., Turner, S. Bain, S., Mallinckrodt, C. & McLeod, K. (2001) Anabolism: Low mechanical signals strengthen long bones. Nature 412:603-604. DOI: 10.1093/ageing/afl082

LiV signals can improve postural stability
Jesse Muir, Stefan Judex, Yi-Xian Qin, Clinton Rubin: Postural instability caused by extended bed rest is alleviated by brief daily exposure to low magnitude mechanical signals Gait & Posture 33 (2011) 429–435

LiV signals accelerate and augment bone repair
Goodship AE, Lawes TJ, Rubin CT.: Low-magnitude high-frequency mechanical signals accelerate and augment endochondral bone repair: preliminary evidence of efficacy. J Orthop Res. 2009 Jul;27(7):922-30

LiV signals can improve bony ingrowth of implants
Rubin, McLeod – Promotion of Bony Ingrowth by Frequency-Specific, Low-Amplitude Mechanical Strain – 1994 Clin Orthop Relat Res.

LiV signals can help to reduce low back pain
Holguin N, Muir J, Rubin C, Judex S (2009) Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest. doi:10.1016/j.spine.2009.02.009 in press.

LiV signals have ability to alter mesenchymal stem cells
Rubin, C., Capilla, E., Luu, Y-K, Busa, B., Rosen, C., Pessin, J. & Judex, S. (2007). Adipogenesis is suppressed by brief, daily exposure to high frequency, extremely low magnitude mechanical signals. Proc. Nat. Acad. Sci. 104:17879-17884